Medical Treatments A doctor may start with aspirin or ibuprofen and move to stronger non steroidal anti inflammatory agents such as naproxen or piroxicam . Sodium pentosanpolysulfate (Elmiron), an experimental drug used for bladder washes, may restore the bladder lining. Another experimental drug called nalmefene (Incystene) may block off pain receptors, thus alleviating this symptom. […]